The objective of present report is investigation of anticonvulsant commotion of Menthapiperita L. &Inularacemosawhich are the well known plants used in Indian traditional medicine for Pulmonary, Gastrointestinal, Antimicrobial, Cardiovascular, Respiratory tract disorders. The hydro alcoholic extract of MenthapiperitaLðanolic extract of Inularacemosawere subjected to various phytochemical tests, then acute toxicity studies were performed followed by antiepileptic activity by models like maxima electroshock (MES) and pentylenetetrazole(PTZ) induced seizures in Wistaralbino rats. Acute toxicity studies were non toxic up to recommended dose of 2000 mg/kg body weight orally as per OECD guidelines no.423. Animals were treated with hydroalcoholic extract of Menthapiperitaðanolic extract of Inularacemosa& combination of both the extracts with 200 mg/kg body weight for 7 days. The ethanolic extract of I. racemosa is more effective in comparison to M. piperita as it gradually decreases the extension phase in both the models and the overall recovery seen was good but the combination is more significant as the results obtained were similar to the standard drugs.
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